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The land on which Wake Forest University now resides and the land on which the original campus resided served for centuries as a place for exchange and interaction for Indigenous peoples, specifically Saura, Catawba, Cherokee, and Lumbee in the current location and Shakori, Eno, Sissipahaw, and Occaneechi in the original campus location. 

americanindiancenter.unc.edu/resources/about-nc-native-communities/